Photo by camilo jimenez on Unsplash
by Timur Maryia
A varied class of tiny signaling proteins known as cytokines is essential for controlling the immune system and preserving immunological homeostasis. By functioning as chemical messengers, these intercellular messengers help cells coordinate and fine-tune the body’s immunological responses. Numerous cells, including immune cells like T cells, B cells, and macrophages as well as non-immune cells like endothelium and epithelial cells, produce cytokines. The body can respond to cytokines locally and systemically, which is why their synthesis and release are well controlled processes. The fundamental mechanism of action of cytokines is their capacity to attach to particular cell-surface receptors, which sets off a series of intracellular signaling cascades that modify gene expression and ultimately cellular activity. Cytokines can work in three different ways: autocrine, which affects the cell that created them; paracrine, which affects neighboring cells; and endocrine, which affects distant target cells by moving via the bloodstream.
Mediating and controlling innate immunity, mediating and regulating adaptive immunity, and inducing hematopoiesis (the creation of blood cells) are the three primary physiologic functions of cytokines. Because of their multifaceted roles, cytokines are able to regulate several immunological responses, including the initiation and resolution of inflammation as well as the clearance of pathogens and the maintenance of self-antigen tolerance. The cytokine family includes several subgroups, each with distinct functions and targets. These include chemokines (which direct cell migration), interferons (which enhance antiviral and anti-tumor defenses), interleukins (which mediate communication between leukocytes), lymphokines (produced by lymphocytes), and tumor necrosis factors (which induce cell death).
Particularly, interleukins are essential for controlling immunological homeostasis. For instance, IL-10 reduces inflammatory reactions, whereas IL-2 encourages T cell development and maturation. Numerous autoimmune and inflammatory diseases have been linked to dysregulation of interleukin signaling in their etiology.
Other important immune regulators, such as mesenchymal stem cells and regulatory T cells, that are essential for preserving the delicate balance of the immune system also interact with and are influenced by cytokines. Autoimmunity, chronic inflammation, and other immune-related disorders can result from a disturbance of this equilibrium.
Other important immune regulators, such as mesenchymal stem cells and regulatory T cells, that are essential for preserving the delicate balance of the immune system also interact with and are influenced by cytokines. Autoimmunity, chronic inflammation, and other immune-related disorders can result from a disturbance of this equilibrium.
As our knowledge of cytokine biology has grown, many treatments that take use of these signaling proteins’ capabilities have been created. Recombinant cytokines, like interferon-α and IL-2, are authorized to treat a number of viral infections and malignancies. Additionally, the therapy of autoimmune illnesses and disorders associated with inflammation may benefit from the use of monoclonal antibodies that target particular cytokines or their receptors.
To sum up, cytokines are complex and multifaceted immune system regulators that are essential for preserving immunological homeostasis. Effective therapy options targeting immune-related disorders require a thorough understanding of the intricate interactions between cytokines and other immunological components.
MCR Committee: Immunology
References:
Wu, J., Xie, A., & Chen, W. (2014). Cytokine regulation of immune tolerance. Burns & trauma, 2(1), 11–17. https://doi.org/10.4103/2321-3868.124771
Van der Meide, P. H., & Schellekens, H. (1996). Cytokines and the immune response. Biotherapy (Dordrecht, Netherlands), 8(3–4), 243–249. https://doi.org/10.1007/BF01877210
Wick, G., Cole, R. K., Dietrich, H., Maczek, C., Müller, P. U., & Hála, K. (1994, January 1). The Obese Strain of Chickens with Spontaneous Autoimmune Thyroiditis as a Model for Hashimoto Disease. Elsevier eBooks. https://doi.org/10.1016/b978-0-08-091736-8.50011-8
Professional, C. C. M. (n.d.). Cytokines. Cleveland Clinic. https://my.clevelandclinic.org/health/body/24585-cytokines
Aryal, S. (2022, September 5). Cytokines- Mechanism of action and Functions. Microbe Notes. https://microbenotes.com/cytokines-mechanism-of-action-and-functions/
What are Cytokines? (2023, April 6). News-Medical. https://www.news-medical.net/health/What-are-Cytokines.aspx